Once the Ottomans decisively eliminated any possible threat from the Safavids at the Battle of Chaldiran in 1514, they turned their attention to the Mamluks, who controlled Syria and Egypt. Not coincidentally, the Mamluks were at the same time preparing for a war with the Ottomans. The two empires were direct competitors when it came to east-west trade, since the Mamluks controlled the Indian Ocean-Red Sea route while the Ottomans were the western terminus of the overland Silk Road from China. So it seemed likely they would come to blows at some point.
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