The feud between the Knights Hospitaller (aka the Knights of Rhodes and, later, the Knights of Malta) and the Ottoman Empire follows the standard big budget movie trilogy playbook, assuming you’re OK with casting the Knights as the protagonists. The saga begins with the Ottoman siege of Rhodes in 1480, from which the heavily outnumbered Knights were able to emerge victorious. They likewise won the finale, the 1565 Great Siege of Malta, mostly by just surviving long enough for a Spanish relief army to come to their rescue. But the middle chapter, the 1522 Siege of Rhodes, went to the Ottomans, who drove the Knights off of Rhodes and eventually to Malta.
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